Abstract
Beta2-adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The compounds exhibited a high potency in a functional cellular assay and a bronchoprotective effect in a guinea pig model which lasted over the complete study period of 5h.
MeSH terms
-
Adrenergic beta-1 Receptor Agonists
-
Adrenergic beta-2 Receptor Agonists*
-
Animals
-
Asthma / drug therapy
-
Bronchodilator Agents / chemical synthesis
-
Bronchodilator Agents / chemistry*
-
Bronchodilator Agents / pharmacology
-
Ethanolamines / chemical synthesis
-
Ethanolamines / chemistry*
-
Ethanolamines / pharmacology
-
Guinea Pigs
-
Heart Rate
-
Humans
-
Receptors, Adrenergic, beta-1 / metabolism
-
Receptors, Adrenergic, beta-2 / metabolism
Substances
-
Adrenergic beta-1 Receptor Agonists
-
Adrenergic beta-2 Receptor Agonists
-
Bronchodilator Agents
-
Ethanolamines
-
Receptors, Adrenergic, beta-1
-
Receptors, Adrenergic, beta-2